ChemicalBook CAS DataBase List 3,5-Dibenzyloxyacetophenone

3,5-Dibenzyloxyacetophenone synthesis

5synthesis methods

Product Name:3,5-Dibenzyloxyacetophenone
CAS Number:28924-21-2
Molecular formula:C22H20O3
Molecular Weight:332.39

51863-60-6 Synthesis

51863-60-6
312 suppliers
$14.00/5g

100-39-0
419 suppliers
$10.00/10 g

28924-21-2
314 suppliers
$22.00/5g

Yield:28924-21-2 86%

Reaction Conditions:

with potassium carbonate in acetone for 18 h;Reflux;

Steps:

6.1 Step 1: 1-(3,5-bis(benzyloxy)phenyl)ethanone
To a clear solution of l-(3,5-dihydroxyphenyl)ethanone (20 g, 131 mmol) in acetone (260 mL) was added potassium carbonate (47.2 g, 342 mmol) and benzyl bromide (35.9 mL, 302 mmol). The reaction mixture was stirred at gentle reflux for 18 h, then the mixture was filtered through a short pad of silica/celite and washed with acetone. The filtrate was concentrated to furnish l-(3,5-Z>/s(benzyloxy)phenyl)ethanone as a white solid (41.6 g, 86% yield).

References:

BIAL - PORTELA & Cª, S.A.;KISS, Laszlo Erno;GUSMÃO DE NORONHA, Rita;ROSA DA COSTA PEREIRA, Carla Patrícia;PINTO, Rui WO2015/16729, 2015, A1 Location in patent:Page/Page column 31

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51863-60-6 Synthesis

51863-60-6
312 suppliers
$14.00/5g

100-44-7 Synthesis