ChemicalBook CAS DataBase List mPEG3-CH2COOH

mPEG3-CH2COOH synthesis

10synthesis methods

Product Name:mPEG3-CH2COOH
CAS Number:16024-60-5
Molecular formula:C9H18O6
Molecular Weight:222.24

3,6,9,12-Tetraoxatridecanoic acid, ethyl ester

66664-66-2
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16024-60-5
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$146.66/0.5g

Yield:16024-60-5 97%

Reaction Conditions:

with sodium hydroxide in tetrahydrofuran;water; for 12 h;Reflux;

Steps:

1-3 Synthesis of methoxy triethylene glycol carboxylic acid

Three-necked flask (300 mL) methoxy triethylene glycol glycol carboxylic acid ethyl ester 12.5g and (50 mmol) placed in 100 mL of THF, was stirred at room temperature. An aqueous solution 100mL of sodium hydroxide 10.0g (250mmol), and the mixture was heated to reflux for 12 hours. Acidified by adding concentrated hydrochloric acid to cool after the reaction solution, THF, water was distilled off to remove insolubles by adding benzene 100mL residue. Distilling off the benzene, it was used in the next reaction and dried under reduced pressure. Colorless liquid crude yield 97%

References:

JP5717138,2015,B2 Location in patent:Paragraph 0029