ChemicalBook CAS DataBase List 3-(BROMOMETHYL)BENZOIC ACID

3-(BROMOMETHYL)BENZOIC ACID synthesis

8synthesis methods

Product Name:3-(BROMOMETHYL)BENZOIC ACID
CAS Number:6515-58-8
Molecular formula:C8H7BrO2
Molecular Weight:215.04

99-04-7 Synthesis

99-04-7
429 suppliers
$8.00/100g

6515-58-8
149 suppliers
$5.00/250mg

Yield:6515-58-8 86%

Reaction Conditions:

with N-Bromosuccinimide;dibenzoyl peroxide in dichloromethane for 2 h;Reflux;

Steps:

4.1 Step 1. Preparation of 3-bromomethylbenzoic acid (Compound 10)
Methylmethylbenzoic acid (2.0 g, 14.7 mmol)And benzoyl peroxide (BPO, 0.036 g, 0.15 mmol)Was dissolved in dichloromethane (6 mL) and heated to reflux,NBS (2.6 g, 14.7 mmol) was added in portions,Continue to heat reflux 2h,After cooling to room temperature, the reaction was quenched with water (10 mL), extracted with dichloromethane (50 mL), washed with water, washed with saturated NaCl, dried over anhydrous Na2SO4,Concentrated to give a pale yellow solid 2.7 g, yield 86%

References:

Zhejiang University;Sheng Rong;Hu Yongzhou;Cao Ji;Li Shan;Qiu Ni;Zhao Mengdan;Yang Bo;He Qiaojun CN106366078, 2017, A Location in patent:Paragraph 0229; 0230; 0231

FullText

614-45-9 Synthesis