Ethyl 4-(bromomethyl)benzoate synthesis
- Product Name:Ethyl 4-(bromomethyl)benzoate
- CAS Number:26496-94-6
- Molecular formula:C10H11BrO2
- Molecular Weight:243.1
64-17-5
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6232-88-8
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$10.00/1g
26496-94-6
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$10.00/5g
Yield:26496-94-6 75%
Reaction Conditions:
with dmap;dicyclohexyl-carbodiimide in dichloromethane at 0; for 12 h;Inert atmosphere;
Steps:
Syntheses of compounds 6e-6j
General procedure: General Method H: To a solution of the acid (1.0 equiv.) in DCM, DCC (1.5 equiv.) was added and followed byalcohol (1.0 equiv.). Catalytic amount of DMAP was then added to the mixture. The reaction mixture was stirredovernight under N2. Water (5.0 mL) was added and the mixture was extracted with DCM. The organic phase waswashed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by silica gelchromatography (EtOA/hexane) to afford pure products.
References:
Liu, Hao;Chen, Li;Zhou, Fei;Zhang, Yun-Xiao;Xu, Ji;Xu, Meng;Bai, Su-Ping [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 14,p. 3089 - 3096] Location in patent:supporting information
94-08-6
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26496-94-6
109 suppliers
$10.00/5g
64-17-5
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$10.00/50g
52780-16-2
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$111.00/5mg
26496-94-6
109 suppliers
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99-94-5
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$9.00/1g
26496-94-6
109 suppliers
$10.00/5g