ChemicalBook CAS DataBase List 3-CHLORO-4-FLUOROPHENYL ISOTHIOCYANATE

3-CHLORO-4-FLUOROPHENYL ISOTHIOCYANATE synthesis

5synthesis methods

Product Name:3-CHLORO-4-FLUOROPHENYL ISOTHIOCYANATE
CAS Number:137724-66-4
Molecular formula:C7H3ClFNS
Molecular Weight:187.62

367-21-5 Synthesis

367-21-5
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$5.00/25g

6160-65-2 Synthesis

6160-65-2
400 suppliers
$6.00/1g

137724-66-4
86 suppliers
$45.00/1 g

Yield:-

Reaction Conditions:

in tetrahydrofuran at 45;

Steps:

General procedure for the preparation of intermediates 2
General procedure: Add compound 1 (1 mmol) to a solution of di(1H-imidzazol-1-yl)methanethione (196 mg, 1.1 mmol) in 5 ml THF. The resulting reaction mixture was heated at 45 °C for 0.5-1.5 h. The reaction was then cooled to room temperature to give a mixture containing intermediate 2. The specific mass of compound 1 required for the reaction was: 3-chloro-4-fluoroaniline (146 mg, 1 mmol), thiazol-2-amine (100 mg, 1 mmol), 4-chloroaniline (128 mg, 1 mmol), 4-fluoroaniline (111 mg, 1 mmol), 1,3-dimethyl-1H-pyrazol-5-amine (111 mg, 1 mmol), 3-chloroaniline (128 mg, 1 mmol), 3,4-dichloroaniline (162 mg, 1 mmol), 4,4-dimethylcyclohexan-1-amine (127 mg, 1 mmol), 4-bromoaniline (172 mg, 1 mmol), naphthalen-1-amine (143 mg, 1 mmol), 4-(trifluoromethyl)aniline (161 mg, 1 mmol), [1,1′-biphenyl]-4-amine (169 mg, 1 mmol), 4-isopropylaniline (135 mg, 1 mmol), 3-(oxazol-5-yl)aniline (160 mg, 1 mmol), 1-methyl-3-phenyl-1H-pyrazol-5-amine (173 mg, 1 mmol).

References:

Xiang, Jiawei;Tao, Lei;Zhou, Yue;Tan, Yuping;Li, Zicheng;Zhao, Yinglan;Sun, Qingxiang;Luo, Youfu [Chemical Papers,2020,vol. 74,# 11,p. 3873 - 3886]

367-21-5 Synthesis

367-21-5
503 suppliers
$5.00/25g