ChemicalBook CAS DataBase List 3-CHLORO-5-METHOXYPYRIDAZINE

3-CHLORO-5-METHOXYPYRIDAZINE synthesis

7synthesis methods

Product Name:3-CHLORO-5-METHOXYPYRIDAZINE
CAS Number:123696-02-6
Molecular formula:C5H5ClN2O
Molecular Weight:144.56

124-41-4 Synthesis

124-41-4
670 suppliers
$12.00/25g

1837-55-4 Synthesis

1837-55-4
171 suppliers
$23.00/250mg

123696-02-6
130 suppliers
$17.00/250mg

Yield:-

Reaction Conditions:

in methanol at 90; for 1 h;

Steps:

131.1
Example 131 2-Chloro-N-(1 -hydroxy-cyclohexylmethyl)-5-(5-methoxy-pyridazin-3- yloxy)-benzamide131.1 3-chloro-5-methoxyDyridazineTo a solution of 3,5-dichloropyridazine (300 mg) in MeOH (2 mL) was added a 5.4 M solution of sodium methoxide in MeOH (0.410 mL) and the reaction mixture was stirred for 1 h at 90°C. It was quenched with H₂0 and extracted with EtOAc. The organic phase was washed with a 5% solution of KHS0₄, a sat. solution of NaHC0₃ and brine, dried over MgS0₄ and concentrated in vacuo to give the crude titled compound as an orange solid.¹H NMR ((CD₃)₂SO) δ: 9.01 (d, J = 2.4 Hz, 1 H), 7.55 (d, J = 2.4 Hz, 1 H), 3.96 (s, 3 H)

References:

ACTELION PHARMACEUTICALS LTD;HILPERT, Kurt;HUBLER, Francis;MURPHY, Mark;RENNEBERG, Dorte WO2012/114268, 2012, A1 Location in patent:Page/Page column 119

123696-01-5 Synthesis