3-cyanopropionamide synthesis

12synthesis methods

Product Name:3-cyanopropionamide
CAS Number:61892-68-0
Molecular formula:C4H6N2O
Molecular Weight:98.1

79-06-1 Synthesis

79-06-1
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61892-68-0
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Yield:61892-68-0 93%

Reaction Conditions:

in hydrogen cyanide;N,N-dimethyl-formamide;toluene;

Steps:

5 EXAMPLE 5

EXAMPLE 5 There were suspended 2 grams of potassium cyanide in a solution of 71.08 grams (1 mole) of acrylamide in 100 ml of dimethyl formamide. Then there were led in at 40° to 50° C. 27 grams (1 mole) of hydrocyanic acid. After the ending of the introduction of hydrocyanic acid the reaction mixture was held for one hour at a temperature between 70° and 100° C. The dimethyl formamide was distilled off to reduce the volume in half and the residue stirred with 150 ml of toluene. There were obtained 91.1 grams of 3-cyanopropionamide (93% of theory) having a Melting Point of 93° to 95° C.

References:

US4313894,1982,A