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Description References
L-Glutamine structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

L-Glutamine Properties

Melting point:
185 °C (dec.) (lit.)
Boiling point:
265.74°C (rough estimate)
32.25 º (c=10, 2 N HCl)
1.47 g/cm3 (20℃)
refractive index 
6.8 ° (C=4, H2O)
Flash point:
storage temp. 
Store below +30°C.
H2O: 25 mg/mL
2.17(at 25℃)
5.0-6.0 (25℃, 0.1M in H2O)
optical activity
[α]20/D +33.0±1°, c = 5% in 5 M HCl
Water Solubility 
Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform.
185 ºC
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
JECFA Number
Stability Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents.
Substances Added to Food (formerly EAFUS)
CAS DataBase Reference
56-85-9(CAS DataBase Reference)
EWG's Food Scores
NCI Dictionary of Cancer Terms
NCI Drug Dictionary
ATC code
NIST Chemistry Reference
EPA Substance Registry System
L-Glutamine (56-85-9)
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  26-24/25-36/37/39-27
WGK Germany  2
RTECS  MA2275100
HS Code  29241900
Toxicity LD50 orally in Rabbit: 7500 mg/kg
NFPA 704
2 0

L-Glutamine price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.16016 (S)-(+)-Glutamine for synthesis 56-85-9 25 g $24.23 2021-03-22 Buy
Sigma-Aldrich 49419 L-Glutamine BioUltra, ≥99.5% (NT) 56-85-9 25g $56.6 2021-03-22 Buy
Sigma-Aldrich 8.16016 (S)-(+)-Glutamine for synthesis 56-85-9 100 g $65.4 2021-03-22 Buy
Sigma-Aldrich 1.00289 L-Glutamine for biochemistry 56-85-9 1 kg $474 2021-03-22 Buy
Sigma-Aldrich 1.00286 L-Glutamine EMPROVE? ESSENTIAL DAB,USP 56-85-9 1000 $479 2021-03-22 Buy

L-Glutamine Chemical Properties,Uses,Production


L-glutamine (chemical formula: C5H10N2O3) is an alpha-amino acid that is one of the 20 amino acids consisting proteins. L-glutamine is a non-essential amino acids and is also the most abundant amino acids in human bodies. It is involved in many important biological processes. For example, it is a building block for the protein synthesis as one key amino acid; it is used in the biosynthesis of urea and purines for nucleic acid synthesis; it is a substrate for the biosynthesis of neurotransmitters; it is also an important sources of cellular energy generation. L-glutamine provides many benefits to the body such as improving gastrointestinal health, aiding the treatment of ulcer and leaky gut, promoting muscle growth, improving diabetes and blood sugar as well as aiding in the treatment of cancer.



Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l .

Chemical Properties

White crystalline powder

Chemical Properties

White, odorless crystals or crystalline powder having a slightly sweet taste. It is soluble in water and practically insoluble in alcohol and in ether. Its solutions are acid to litmus. It melts with decomposition at about 185°C.

Chemical Properties

L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis.


Occurrences in nature
Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources
Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices.
Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease.


L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.


L-Glutamine is one of the 20 amino acids encoded by the standard genetic code. Its codons are CAA and CAG. Glutamine is a substance naturally produced in the body to help regulate cell growth and function. There may also be man-made versions of these subs


amine protecting agent


ChEBI: An optically active form of glutamine having L-configuration.


By isolation from sugar beet juice.

brand name

Nutrestore (Nutritional Restart).

Biological Functions

Glutamine plays a role in a variety of biochemical functions, including :
Protein synthesis, as any other of the 20 proteinogenic amino acids
Regulation of acid-base balance in the kidney by producing ammonium
Cellular energy, as a source, next to glucose
Nitrogen donation for many anabolic processes, including the synthesis of purines
Carbon donation , as a source , refilling the citric acid cycle
Nontoxic transporter of ammonia in the blood circulation.

Synthesis Reference(s)

Tetrahedron: Asymmetry, 17, p. 245, 2006 DOI: 10.1016/j.tetasy.2005.12.023
Journal of the Chemical Society, p. 3315, 1949 DOI: 10.1039/JR9490003315

Safety Profile

Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Glutamine has been used as a GI protectant and in an attempt to enhance GI healing in conditions where GI epithelium is damaged (Parvo enteritis, chemotherapy, etc.).
A study that evaluated the efficacy of glutamine supplementation in cats with methotrexate-induced enteritis found no difference between cats supplemented with glutamine and those that were not. (Marks, Cook et al. 1999)

Purification Methods

Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.]

Producing and consuming organs

Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut.
The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid - base balance, activated immune cells, and many cancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs.
Examples for the usage of glutamine
In catabolic states of injury and illness, glutamine becomes conditionally essential (requiring intake from food or supplements). Glutamine has been studied extensively over the past 10–15 years, and has been shown to be useful in treatment of injuries, trauma, burns, and treatment - related side effects of cancer, as well as in wound healing for postoperative patients. Glutamine is also marketed as a supplement used for muscle growth in weight lifting , body building, endurance, and other sports. Evidence indicates glutamine, when orally loaded, may increase plasma HGH levels by stimulating the anterior pituitary gland. In biological research, L-glutamine is commonly added to the media in cell culture. However, the high level of glutamine in the culture media may inhibit other amino acid transport activities.

L-Glutamine Preparation Products And Raw materials

Raw materials

Preparation Products

L-Glutamine Suppliers

Global( 739)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258 CHINA 29954 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20012 60
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+86-371-66670886 China 20914 58
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0371-55170693 CHINA 22607 55
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+86-571-56059825 CHINA 8909 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-34979012 CHINA 739 60
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 26751 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967 CHINA 1009 58

Related Qustion

View Lastest Price from L-Glutamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 L-Glutamine
US $6.80 / KG 100KG 98% 1-100mt Baoji Guokang Bio-Technology Co., Ltd.
2021-11-26 L-Glutamine
US $10312.00 / T 1T 99% 10 tons Baoji Guokang Bio-Technology Co., Ltd.
2021-11-25 L-Glutamine
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd

L-Glutamine Spectrum

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