3-dimethylaminomethyl-4-nitroindole synthesis

11synthesis methods

Product Name:3-dimethylaminomethyl-4-nitroindole
CAS Number:7150-46-1
Molecular formula:C11H13N3O2
Molecular Weight:219

50-00-0 Synthesis

50-00-0
838 suppliers
$10.00/25g

4769-97-5 Synthesis

4769-97-5
339 suppliers
$6.00/250mg

124-40-3
501 suppliers
$18.00/100ml

7150-46-1
11 suppliers
$237.00/1g

Yield:7150-46-1 4250 mg

Reaction Conditions:

with zinc(II) chloride in methanol at 20;

Steps:

20.1 Step 1: Preparation of Y-1

Add 4-nitroindole (4000mg), NH(CH3)2(13.58ml, 2mol/lin MeOH), HCHO (2.2ml, 37%), ZnCl2(5048mg) and 10ml Methanol. After stirring at room temperature for 2 h, additional NH(CH3)2 (2.46ml), HCHO (0.5ml) were added. After stirring for 4 hours, LC-MS showed that the raw materials were consumed completely. NaOH solution was added to adjust the pH to about 13, EA was added to dilute, and the insoluble solid was removed by filtration. The filtrate was extracted with EA, and after the sodium sulfate solid was dried, the solvent was spin-dried to obtain a yellow solid, which was then beaten with PE/EA 10:1 to obtain 4250 mg of a yellow solid.

References:

CN115806557,2023,A Location in patent:Paragraph 0412-0416

4769-97-5 Synthesis

4769-97-5
339 suppliers
$6.00/250mg

51-80-9 Synthesis