ChemicalBook CAS DataBase List 3-Fluorobenzoic acid

3-Fluorobenzoic acid synthesis

11synthesis methods

Product Name:3-Fluorobenzoic acid
CAS Number:455-38-9
Molecular formula:C7H5FO2
Molecular Weight:140.11

It is obtained by deaminating 2-amino-5-chlorobenzoic acid.

456-48-4 Synthesis

456-48-4
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455-38-9
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Yield:455-38-9 98%

Reaction Conditions:

with oxygen;copper(II) acetate monohydrate;cobalt(II) diacetate tetrahydrate in water at 70; under 760.051 Torr; for 12 h;

Steps:

9 Example 9 Preparation of m-fluorobenzoic acid by oxidation of m-fluorobenzaldehyde

Under atmospheric pressure oxygen, water (2 mL), m-fluorobenzaldehyde (1 mmol), Cu(OAc)₂·H₂O (0.003 mmol, 0.3% mole fraction) and Co(OAc)₂·4H₂O (0.003mmol, 0.3% mole fraction) was added to a 15mL glass reaction tube, and an oxygen balloon was connected.The reaction tube was placed in an oil bath heated to 70°C in advance to stir the reaction for 12 hours. After the reaction was completed, the temperature was lowered, the crude product solid was centrifuged, and then ultrasonically washed with 3 mL of water, centrifuged, and dried to constant weight to obtain the target product. The separation yield was 98 %.

References:

CN111116348,2020,A Location in patent:Paragraph 0028-0029

456-47-3 Synthesis