ChemicalBook CAS DataBase List 3-tert-Butylphenol

3-tert-Butylphenol synthesis

7synthesis methods

Product Name:3-tert-Butylphenol
CAS Number:585-34-2
Molecular formula:C10H14O
Molecular Weight:150.22

507-20-0 Synthesis

507-20-0
354 suppliers
$13.00/25mL

108-95-2 Synthesis

108-95-2
708 suppliers
$14.00/25g

98-54-4
403 suppliers
$15.00/25g

585-34-2
198 suppliers
$11.00/5g

Yield:-

Reaction Conditions:

with sulfuric acid at 150; for 3 h;Green chemistry;

Steps:

1.1-3.1 Example 1
(1) 10g of phenol,0.1g white clay andAdd 50mg of sulfuric acid to the round bottom reaction bottle, control the reaction temperature at 150 , add 15ml of tert-butyl chloride dropwise, drop the mixture and stir for 3 hours. After the reaction is completed, filter the catalyst and pour the reaction solution into 100ml of water To obtain an organic phase layer and an inorganic phase layer, adding 300 ml of ethyl acetate and extracting three times, combining to obtain an organic phase layer solution, the organic phase layer solution was dried over anhydrous NaSO4, ethyl acetate was recovered, and distilled under reduced pressure,Collect 125 130 / 20mmHg fractions to obtain m-tert-butylphenol with a purity of 98.0%,

References:

China Pharmaceutical University;Huang Dechun;Zhou Yahan;Zhao Bingbing;Chen Jiaxin;Chen Wei CN110903171, 2020, A Location in patent:Paragraph 0023-0024; 0027-0028; 0030-0031

5369-19-7 Synthesis