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ChemicalBook CAS DataBase List 3-(Trifluoromethyl)pyridine-2-carboxylic acid

3-(Trifluoromethyl)pyridine-2-carboxylic acid synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 82 percent / bromotrimethylsilane / various solvent(s) / 72 h / Heating
2: 68 percent / butyllithium / hexane; toluene / 2 h / -75 °C

References:

Cottet, Fabrice;Marull, Marc;Lefebvre, Olivier;Schlosser, Manfred [European Journal of Organic Chemistry,2003,# 8,p. 1559 - 1568]

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