Methyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate synthesis
- Product Name:Methyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
- CAS Number:310431-29-9
- Molecular formula:C9H9N3O3
- Molecular Weight:207.19
310431-26-6
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60100-09-6
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310431-29-9
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Yield:310431-29-9 90%
Reaction Conditions:
at 165; for 6 h;
Steps:
19.C
C. 5-Methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Methyl Ester Compound B (38 g, 179 mmol) was combined with formamide (400 mL) and heated to 165° C. for 6 hr. The reaction was diluted with water (5 mL), extracted with ethyl acetate (3*10 mL), dried (Na2SO4) and concentrated. The crude material was purified by washing with ether/hexanes (7/3) to provide 33.4 g (90%) of Compound C as a white solid. ESI MS: [M-H]-=206.0
References:
US6982265,2006,B1 Location in patent:Page/Page column 33
40318-15-8
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310431-29-9
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3780-42-5
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310431-29-9
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623-43-8
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310431-29-9
47 suppliers
$45.00/10mg