4-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:4-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
- CAS Number:35212-95-4
- Molecular formula:C10H7ClO2S
- Molecular Weight:226.68
6361-22-4
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$17.00/250mg
2365-48-2
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$14.00/25g
35212-95-4
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$58.00/1g
Yield:35212-95-4 92%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 60;
Steps:
1 Methyl 4-chlorobenzo[b]thiophene-2-carboxylate
2-chloro-6-nitrobenzaldehyde (556.5 mg, 3.0 mmol), methyl mercaptoacetate (274 uL, 3.0 mmol), K2C03 (414 mg, 3.0 mmol) and DMF (10 mL) were added to a 50 ml round bottom flask, and stirred at 60 °C overnight. The DMF was removed in vacuo, and the crude residue was dissolved in ethyl acetate (30 ml) and water (10 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2x). The combined organics were dried (MgSO4) and concentrated to give title compound (621 mg, 92%). ‘H NMR (CDCI3, 400 MHz) ? 8.15 (d, IH, J 0.4 Hz), 7.68 (ddd, 1H, J 0.8, 1.6, 7.2 Hz), 7.357.31 (m, 2H), 3.89 (s, 3H).
References:
WO2016/191366,2016,A1 Location in patent:Page/Page column 34; 35
387-45-1
381 suppliers
$9.00/1g
2365-48-2
375 suppliers
$14.00/25g
35212-95-4
51 suppliers
$58.00/1g
83-38-5
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$6.00/10g
2365-48-2
375 suppliers
$14.00/25g
35212-95-4
51 suppliers
$58.00/1g