4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester synthesis
- Product Name:4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester
- CAS Number:39497-01-3
- Molecular formula:C11H9NO3
- Molecular Weight:203.19
67-56-1
15733-89-8
39497-01-3
Example II Synthesis of 2-quinoline triazole derivatives: 2-hydroxyquinoline-4-carboxylic acid (500 mg, 2.65 mmol) was suspended in anhydrous methanol and concentrated sulfuric acid (96%, 40 drops) was added slowly. The reaction mixture was heated to reflux until the solution became clear. Stirring was continued under reflux conditions for 18 hours (the reaction was monitored by LC-MS until the starting material disappeared completely). Upon completion of the reaction, it was cooled to room temperature and a white precipitate was precipitated. The precipitate was collected by filtration and washed with diethyl ether to give a white solid product in 70% yield (0.38 g). The product was characterized by 1H NMR (DMSO, INOVA-400): δ 3.91 (s, 3H), 6.88 (d, 1H, J = 1.6 Hz), 7.22 (td, 1H, Jt = 7.5 Hz, 0.8 Hz), 7.35 (d, 1H, J = 8.4 Hz), 7.55 (td, 1H, Jt = 7.2 Hz).
21233-61-4
59 suppliers
$55.00/10mg
39497-01-3
47 suppliers
$45.00/50mg
Yield:39497-01-3 75%
Reaction Conditions:
with fluorine in water;acetonitrile;Ambient temperature;
References:
Puy, Michael Van Der;Nalewajek, David;Wicks, Gene E. [Tetrahedron Letters,1988,vol. 29,# 35,p. 4389 - 4392]
67-56-1
782 suppliers
$9.00/25ml
15733-89-8
280 suppliers
$14.14/1gm:
39497-01-3
47 suppliers
$45.00/50mg
15733-89-8
280 suppliers
$14.14/1gm:
144-55-8
1372 suppliers
$10.00/25g
39497-01-3
47 suppliers
$45.00/50mg