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2-Hydroxy-4-quinolincarboxylic acid

2-Hydroxy-4-quinolincarboxylic acid structure

CAS No.: 15733-89-8

Chemical Name:: 2-Hydroxy-4-quinolincarboxylic acid

Synonyms: 2-Hydroxy-4-quinolinecarboxylic acid;2-Oxo-1,2-dihydroquinoline-4-carboxylic acid;AKOS AUF0188;RARECHEM AQ NN 0221;IFLAB-BB F1918-0080;2-hydroxycinchoninic;4-carboxycarbostyril;Cinchocaine impurity B;Piraxostat Impurity 7;2-hydroxy-cinchoninicaci

CBNumber:: CB3132467

Molecular Formula:: C10H7NO3

Molecular Weight:: 189.17

MDL Number:: MFCD00023942

MOL File:: 15733-89-8.mol

MSDS File:: SDS

Last updated:2026-05-28 00:57:40

Product description	Number	Pack Size	Price
2-Oxo-1,2-dihydroquinoline-4-carboxylic acid Aldrich^CPR	CDS019980	100 mg	$77.9
2-Hydroxyquinoline-4-carboxylic Acid >98.0%(HPLC)(T)	H1016	5g	$36
2-Hydroxyquinoline-4-carboxylic Acid >98.0%(HPLC)(T)	H1016	25g	$105
2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID 97%	31350	25G	$40
2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID 97%	31350	100G	$100
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2-Hydroxy-4-quinolincarboxylic acid Properties

Melting point	350°C
Boiling point	403.6±45.0 °C(Predicted)
Density	1.429±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	2.76±0.20(Predicted)
color	Yellow to Dark Yellow
BRN	148331
InChI	InChI=1S/C10H7NO3/c12-9-5-7(10(13)14)6-3-1-2-4-8(6)11-9/h1-5H,(H,11,12)(H,13,14)
InChIKey	MFSHNFBQNVGXJX-UHFFFAOYSA-N
SMILES	N1C2=C(C=CC=C2)C(C(O)=O)=CC1=O
LogP	0.3 at 25℃ and pH7
CAS DataBase Reference	15733-89-8(CAS DataBase Reference)
FDA UNII	Z1Q2K479UQ
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-36

WGK Germany

WGK 3

RTECS

GD3869000

HazardClass

IRRITANT

HS Code

29337900

Storage Class

13 - Non Combustible Solids

Toxicity

mouse,LD,intraperitoneal,> 500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 338, 1953.

REACH Registrations

Active

NFPA 704

	0
2		0

2-Hydroxy-4-quinolincarboxylic acid price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS019980	2-Oxo-1,2-dihydroquinoline-4-carboxylic acid Aldrich^CPR	15733-89-8	100 mg	$77.9	2026-04-30	Buy
TCI Chemical	H1016	2-Hydroxyquinoline-4-carboxylic Acid >98.0%(HPLC)(T)	15733-89-8	5g	$36	2026-04-30	Buy
TCI Chemical	H1016	2-Hydroxyquinoline-4-carboxylic Acid >98.0%(HPLC)(T)	15733-89-8	25g	$105	2026-04-30	Buy
AstaTech	31350	2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID 97%	15733-89-8	25G	$40	2026-04-30	Buy
AstaTech	31350	2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID 97%	15733-89-8	100G	$100	2026-04-30	Buy

Product number	Packaging	Price	Buy
CDS019980	100 mg	$77.9	Buy
H1016	5g	$36	Buy
H1016	25g	$105	Buy
31350	25G	$40	Buy
31350	100G	$100	Buy

2-Hydroxy-4-quinolincarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

Solid

Uses

1,2-Dihydro-2-oxo-4-quinolinecarboxylic Acid is a chemical constituent of vinegar Schisandra chinensis and is used as a indicator reagent in marking security documents.

Definition

ChEBI: 2-oxo-1,2-dihydroquinoline-4-carboxylic acid is a quinolinemonocarboxylic acid. It is a conjugate acid of a 2-oxo-1,2-dihydroquinoline-4-carboxylate.

Synthesis

141-82-2

91-56-5

15733-89-8

1. Add 400kg of recovered glacial acetic acid to the 1000L reactor and start stirring. 2. 100kg of indigo, 160kg of malonic acid and 15kg of sodium acetate were added sequentially to the reactor to ensure adequate mixing. 3. The reaction mixture was heated to reflux and the reflux reaction was maintained for 6 hours. 4. Upon completion of the reaction, the acetic acid was removed by distillation under reduced pressure. 5. 300 kg of deionized water was added to the reaction mixture and stirred to promote crystal formation. 6. 6. The solid product was collected by filtration, washed with 30 kg of cold glacial acetic acid, and then rinsed with 30 kg of cold methanol to obtain the wet product of 2-quinolinone-4-carboxylic acid. 7. The wet product was dried at 45-70 °C for 24 h. 125 kg of 2-quinolinone-4-carboxylic acid was finally obtained with a yield of 97.3% and a liquid phase purity of 99.6%.

References

[1] Patent: CN108101842, 2018, A. Location in patent: Paragraph 0021; 0023
[2] Synthetic Communications, 2005, vol. 35, # 17, p. 2243 - 2250
[3] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 44
[4] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0271-0274
[5] Chemische Berichte, 1914, vol. 47, p. 358

2-Hydroxy-4-quinolincarboxylic acid Preparation Products And Raw materials

Raw materials

Malonic acid Isatin

Preparation Products

2-CHLOROQUINOLINE-4-CARBOXYLIC ACID QUINOLINE-4-CARBOXYLIC ACID 1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE-4-CARBOXYLIC ACID 4-Quinolinecarboxylic acid, 2-chloro-, ethyl ester

2-Hydroxy-4-quinolincarboxylic acid Suppliers

Global( 311)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	283	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	923	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 2-Hydroxy-4-quinolincarboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2-Hydroxy-4-quinolincarboxylic acid 15733-89-8	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
2025-04-04	2-Hydroxy-4-quinolincarboxylic acid 15733-89-8		1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-01-18	2-Hydroxy-4-quinolincarboxylic acid 15733-89-8	$88.00	1KG	99%	100000T	Xiamen Wonderful Bio Technology Co., Ltd.

2-Hydroxy-4-quinolincarboxylic acid
15733-89-8
$1.10
99.00%
Dideu Industries Group Limited

2-Hydroxy-4-quinolincarboxylic acid
15733-89-8
98%
Henan Aochuang Chemical Co.,Ltd.

2-Hydroxy-4-quinolincarboxylic acid
15733-89-8
$88.00
99%
Xiamen Wonderful Bio Technology Co., Ltd.

2-Hydroxy-4-quinolincarboxylic acid Spectrum

2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)MS 2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)¹HNMR 2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)¹³CNMR 2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)IR1 2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)IR2

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IFLAB-BB F1918-0080 AKOS AUF0188 1,2-DIHYDRO-2-OXOQUINOLINE-4-CARBOXYLIC ACID 2-HYDROXY-4-QUINOLINCARBOXYLIC ACID 2-HYDROXYCINCHONINIC ACID RARECHEM AQ NN 0221 1,2-dihydro-2-oxo-4-quinolinecarboxylicaci 2-hydroxy-cinchoninicaci 4-carboxycarbostyril 2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID 98% 2-hydroxycinchoninic 2-Hydroxyquinoline-4-carboxylic acid hydrate, 98+% ##USE H29247## 2-Hydroxyquinoline-4-carboxylic acid hydrate, 98+% 4-quinolinecarboxylic acid, 2-hydroxy- 2-Hydroxyquinoline-4-carboxylic acid, 98+% 2-oxo-1,2-dihydroquinoline-4-carboxylic acid(SALTDATA: 0.7H2O) 2-oxo-1,2-dihydroquinoline-4-carboxylic acid 0.7H2O 2-Hydroxyquinolin-4-carboxylic acid 1,2-Dihydro-2-oxoquinoline-4-carboxylic Acid 2-Hydroxycinchoninic Acid 2-oxo-4-quinolinecarboxylic acid 1,2-Dihydro-2-oxo-quinolin-4-carboxylic acid Methyl 2-hydroxyquinoline-4-carboxylate 2-Hydroxy-4-quinolincarboxylic acid ISO 9001：2015 REACH 1,2-Dihydro-2-Oxoquinoline-4-CarboxylicAci Cinchocaine EP Impurity B (2-Hydroxyquinoline-4-Carboxylic Acid) 2-Hydroxyquinoline-4-carboxylicAcid> Cinchocaine impurity B 1,2-Dihydro-2-oxo-4-Cinchocaine EP Impurity B Cinchocaine EP Impurity B 4-Quinolinecarboxylicacid, 1,2-dihydro-2-oxo- 1,2-Dihydro-2-oxo-4-quinolinecarboxylic acid Cinchocaine Hydrochloride EP Impurity B Piraxostat Impurity 7 Cinchocaine Hydrochloride Imp. B (EP): 2-Hydroxyquinoline-4- Cinchocaine impurity B【Y0002032】 Cinchocaine Hydrochloride Impurity B 2-Hydroxy-4-quinolinecarboxylic acid 2-Oxo-1,2-dihydroquinoline-4-carboxylic acid 15733-89-8 Hydroxyquinolines Quinolines Building Blocks Heterocyclic Building Blocks Hydroxyquinolines Quinolines Intermediate