4-(4-BROMOPHENOXY)BENZONITRILE synthesis
- Product Name:4-(4-BROMOPHENOXY)BENZONITRILE
- CAS Number:330792-93-3
- Molecular formula:C13H8BrNO
- Molecular Weight:274.11
Yield:330792-93-3 87.2%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 100; for 16 h;
Steps:
15.a
(4-cyanophenyl)(4-bromophenyl)ether. Under nitrogen, the mixture of 4-fluorobenzonitrile (7.35 g, 60.68 mmol), 4-bromophenol (10 g, 57.8 mmol) and potassium carbonate (12 g, 1.5 eq) in DMF (100 mL) was stirred at 100° C. for 16 h and then filtered. After rotary evaporation, the residue was dissolved in ethyl acetate and washed with 1N NaOH solution to remove unreacted phenol. The organic solution was dried and passed through a short silica gel column to remove the color and minor phenol impurity. Evaporation of the solution gave (4-cyanophenyl)(4-bromophenyl)ether (13.82 g, yield 87.2%) as a white solid. 1H NMR (300 MHz, DMSO-d6): δ 7.83 (d, 2H), 7.63 (d, 2H), 7.13 (d, 2H) and 7.10 (d, 2H) ppm.
References:
US2007/293457,2007,A1 Location in patent:Page/Page column 47
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