4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE synthesis
- Product Name:4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE
- CAS Number:90035-20-4
- Molecular formula:C14H9F3O2
- Molecular Weight:266.22
402-45-9
459-57-4
90035-20-4
Intermediate 52: Synthesis of 4-{[4-(trifluoromethyl)phenyl]oxy}benzaldehyde; To a solution of 4-(trifluoromethyl)phenol (9.1 g, 56 mmol, 1.2 eq.) in N,N-dimethylformamide (DMF, 100 mL) was added sequentially cesium carbonate (22.8 g, 70 mmol, 1.5 eq.) and 4-fluorobenzaldehyde (5 mL, 46.6 mmol, 1.0 equiv). The reaction mixture was stirred and mixed at room temperature, then warmed to 85 °C and stirred continuously for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove the insoluble salt. The filtrate was concentrated under reduced pressure to remove the solvent, and the crude product obtained was purified by fast column chromatography (silica gel, cyclohexane/ethyl acetate=70/30, v/v) to afford the target product 4-(4'-trifluoromethyl)phenoxybenzaldehyde (9.0 g, 73% yield) as a colorless oil. The structure of the product was confirmed by 1H NMR (CDCl3, δ 9.97 (s, 1H), 7.91 (m, 2H), 7.67 (d, J=8.6 Hz, 2H), 7.20-7.11 (m, 4H)) and LCMS ((M+H)+=267, retention time Rt=3.53 min).
402-45-9
359 suppliers
$20.00/5/ G
459-57-4
595 suppliers
$6.00/25g
90035-20-4
49 suppliers
$60.00/100mg
Yield:90035-20-4 100%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 100;
References:
Chen, Tao;Zhang, Rui;Wang, Yu-Xia;Gao, Meng-Qi;Chen, Qiong;Zhu, Xiao-Lei;Yang, Guang-Fu [Letters in drug design and discovery,2022,vol. 19,# 4,p. 263 - 268]
402-45-9
359 suppliers
$20.00/5/ G
555-16-8
560 suppliers
$5.00/5g
90035-20-4
49 suppliers
$60.00/100mg
128796-39-4
432 suppliers
$10.00/5g
555-16-8
560 suppliers
$5.00/5g
90035-20-4
49 suppliers
$60.00/100mg