4-(4H-1,2,4-TRIAZOL-4-YL)BENZOIC ACID synthesis
- Product Name:4-(4H-1,2,4-TRIAZOL-4-YL)BENZOIC ACID
- CAS Number:157069-48-2
- Molecular formula:C9H7N3O2
- Molecular Weight:189.17
167626-25-7
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157069-48-2
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Yield: 99%
Reaction Conditions:
Stage #1:4-(4H-1,2,4-triazol-4-yl)benzoic acid ethyl ester with water;sodium hydroxide in ethanol for 0.5 h;Reflux;
Stage #2: with hydrogenchloride in water
Steps:
88
Ester 124 (6.8 g, 31.3 mmol) was dispersed into ethanol (70 ml), 1N sodium hydroxide (70 ml) was added, heated and refluxed for 30 minutes. After reaction ended, the solvent was distilled in vacuum, and the residu obtained was dissolved in water. 1N hydrochloric acid (70 ml) was added, precipitated colorless solid was filtered out, washed with water and dried in vacuum, yielding 125 (5.88 g, 99%). > mp330°C APCI-MS m/z 190[M+H]+ IR(Nujol) 1692, 1609cm-1
References:
Tohoku University EP2103611, 2009, A1 Location in patent:Page/Page column 83
16114-05-9
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150-13-0
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157069-48-2
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628-36-4
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150-13-0
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157069-48-2
82 suppliers
$22.00/100mg
628-36-4
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150-13-0
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122-51-0
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624-84-0
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157069-48-2
82 suppliers
$22.00/100mg
150-13-0
939 suppliers
$5.00/25g
122-51-0
506 suppliers
$10.00/5ml
624-84-0
251 suppliers
$10.00/1g
157069-48-2
82 suppliers
$22.00/100mg