ChemicalBook CAS DataBase List 4-Amino-3,5-dichloroacetophenone

4-Amino-3,5-dichloroacetophenone synthesis

5synthesis methods

Product Name:4-Amino-3,5-dichloroacetophenone
CAS Number:37148-48-4
Molecular formula:C8H7Cl2NO
Molecular Weight:204.05

4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of cough antiasthmatic crepustin. It was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5 °C, after the addition is completed, immediately put into ice water to precipitate the precipitate, filter, and wash with water to obtain the crude product Recrystallize with ethanol to obtain the finished product of 3,5-dichloro-4-aminoacetophenone.

75-36-5 Synthesis

75-36-5
560 suppliers
$17.92/100G

608-31-1 Synthesis

608-31-1
307 suppliers
$12.00/25g

37148-48-4
369 suppliers
$6.00/1g

Yield:37148-48-4 88.6%

Reaction Conditions:

with iron(III) chloride in chloroform at 0 - 20; for 6 h;

Steps:

2.1 Preparation of 3,5-dichloro-4-aminoacetophenone
A 250 mL three-necked flask was charged with 8.3 g of 2,6-dichloroaniline,After adding 50 mL of chloroform and stirring to disperse,Add ferric chloride 30g,Control temperature 0 ° C was added dropwise acetyl chloride 8.8g,After completion of the dropwise addition at room temperature for 6 hours,After acidification,Suction filtration,Washed with water to give 9.0 g of light yellow 3,5-dichloro-4-aminoacetophenone,Yield 88.6%, HPLCTesting, purity 99.5%

References:

Shanghai Chemical Institute;Xu Zhongjie;Luo Yong;Sun Kai;Yang Weicheng;Sun Wen;Li Meihua;Tu Yahui;Zhong Jiaqi;Fang Chao CN105968021, 2016, A Location in patent:Paragraph 0168-0169

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99-92-3 Synthesis

99-92-3
507 suppliers
$6.00/10g

6953-83-9
44 suppliers
$170.00/50 mg

37148-48-4
369 suppliers
$6.00/1g

References

108-24-7
5 suppliers
$14.00/250ML

608-31-1 Synthesis

608-31-1
307 suppliers
$12.00/25g

37148-48-4
369 suppliers
$6.00/1g

References

99-92-3 Synthesis

99-92-3
507 suppliers
$6.00/10g

37148-48-4
369 suppliers
$6.00/1g

References

7782-50-5
2 suppliers
$373.00/454g

99-92-3 Synthesis

99-92-3
507 suppliers
$6.00/10g

64-19-7 Synthesis

64-19-7
1518 suppliers
$10.00/25ML

37148-48-4
369 suppliers
$6.00/1g

634-93-5 Synthesis

634-93-5
198 suppliers
$12.00/5g

References

4-Amino-3,5-dichloroacetophenone Related Search:

Acetophenone 4'-Methylacetophenone Acetylacetone Glycine Betaine 2-Aminoecetophenone Dichloroacetonitrile Acetyl chloride 3-Aminoacetophenone 4'-Hydroxyacetophenone