4-Amino-3-nitrobenzophenone synthesis
- Product Name:4-Amino-3-nitrobenzophenone
- CAS Number:31431-19-3
- Molecular formula:C13H10N2O3
- Molecular Weight:242.23
82571-93-5
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$55.00/250mg
31431-19-3
164 suppliers
$45.00/500mg
Yield: 45%
Reaction Conditions:
with ammonium hydroxide;N-ethyl-N,N-diisopropylamine in tetrahydrofuran at 20; for 24 h;
Steps:
23 4-amino-3-nitrophenyl) (phenyl) methanone (A30)
Add A29 (130 mg, 530.16 μmol), ammonia (25%, 90 μL, 583.18 μmol), N, N-diisopropylethylamine (109 μL, 636.19 μmol), and tetrahydrofuran (2 mL) to a 10 mL eggplant-shaped bottle at room temperature The reaction took 24 hours. After the reaction was detected by TLC, the reaction solvent was concentrated and removed. After adding 1 mol / L hydrochloric acid (15 mL), the mixture was extracted with ethyl acetate (10 mL × 3). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain Crude product. The crude product was subjected to silica gel column chromatography (petroleum ether / ethyl acetate, volume ratio 5: 1) to obtain 58 mg of a yellow solid with a yield of 45%. mp: 140-142 ° C
References:
China Pharmaceutical University;Jiao Yu;Liu Yong;Lu Tao;Peng Qi;Chen Yadong;Tang Weifang CN110818609, 2020, A Location in patent:Paragraph 0094;0095; 0276; 0279; 0280
56107-02-9
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31431-19-3
164 suppliers
$45.00/500mg
53502-23-1
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31431-19-3
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2243-80-3
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31431-19-3
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1775-95-7
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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31431-19-3
164 suppliers
$45.00/500mg