ChemicalBook CAS DataBase List 4-Methylbenzophenone

4-Methylbenzophenone synthesis

11synthesis methods

Product Name:4-Methylbenzophenone
CAS Number:134-84-9
Molecular formula:C14H12O
Molecular Weight:196.24

4-Methylbenzophenone can be used as an organic reagent,it can be synthesized from 4-Bromotoluene and Benzeneaceticacid,.alpha.-oxo-,potassiumsalt, with hydrogenchloride in tetrahydrofuran.

5720-05-8
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$5.00/1g

100-52-7 Synthesis

100-52-7
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$17.30/2g

134-84-9
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$7.00/10g

Yield:134-84-9 93%

Reaction Conditions:

with [Pd(2-((1-naphthalenyl)methylene)-N-phenylhydrazinecarbothioamide)Cl(PPh₃)];caesium carbonate in toluene at 110; for 12 h;

Steps:

General Procedure for Coupling of Arylboronic Acids with Aromatic Aldehydes
General procedure: Arylboronic acid (1 mmol), aromatic aldehyde (1.5 mmol), Cs₂CO₃ (3.0 mmol), catalyst (5.0 mol%) and toluene (3.0 ml) were taken in a round-bottom flask. The mixture was then heated under reflux for 12 h under aerobic conditions and monitored by TLC. At the end of the specified time, the reaction mixture was cooled to room temperature, quenched with 1 N HCl (5 ml) and finally extracted with ethyl acetate (2 × 5 ml). The combined extracts were dried over anhydrous Na₂SO₄ and the solvent was removed under reduced pressure. The residue obtained was subjected to flash chromatography on a silica gel column to purify the desired ketone.

References:

Prabhu, Rupesh Narayana;Ramesh, Rengan [Tetrahedron Letters,2017,vol. 58,# 5,p. 405 - 409] Location in patent:supporting information

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