4-Benzylisoquinoline synthesis

13synthesis methods

Product Name:4-Benzylisoquinoline
CAS Number:5632-14-4
Molecular formula:C16H13N
Molecular Weight:219.28

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100-44-7 Synthesis

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Yield:5632-14-4 95%

Reaction Conditions:

with bis(acetylacetonato)palladium(II);caesium carbonate;tricyclohexylphosphine in tetrahydrofuran at 60; for 8 h;

Steps:

4 Example 4:

In the reaction tube, 1.0 mmol of quinoline, 1.1 mmol of benzyl chloride, and Catalyst Pd(acac)2 0.05mmol, PCy3 0.11mmol, Cs2CO3 1.5mmol,Add 3 mL of tetrahydrofuran as a solvent and react at 60 ° C for 8 hours.After the reaction, the reaction solution was concentrated, and the corresponding product was separated by column chromatography.The isolated yield was 95%.

References:

CN110606829,2019,A Location in patent:Paragraph 0032-0034