4-broMo-1-Methoxy-2-(Methylsulfonyl)benzene synthesis
- Product Name:4-broMo-1-Methoxy-2-(Methylsulfonyl)benzene
- CAS Number:90531-99-0
- Molecular formula:C8H9BrO3S
- Molecular Weight:265.12
23095-05-8
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$19.00/1g
74-88-4
351 suppliers
$15.00/10g
90531-99-0
17 suppliers
$380.00/250mg
Yield:90531-99-0 87%
Reaction Conditions:
Stage #1: 5-bromo-2-methoxybenzenesulfonyl chloridewith sodium hydrogencarbonate;sodium sulfite in 1,4-dioxane;water at 70; for 1 h;
Stage #2: methyl iodide in N,N-dimethyl-formamide; for 2 h;
References:
Lazerwith, Scott E.;Bahador, Gina;Canales, Eda;Cheng, Guofeng;Chong, Lee;Clarke, Michael O.;Doerffler, Edward;Eisenberg, Eugene J.;Hayes, Jaclyn;Lu, Bing;Liu, Qi;Matles, Mike;Mertzman, Michael;Mitchell, Michael L.;Morganelli, Philip;Murray, Bernard P.;Robinson, Margaret;Strickley, Robert G.;Tessler, Megan;Tirunagari, Neeraj;Wang, Jianhong;Wang, Yujin;Zhang, Jennifer R.;Zheng, Xubin;Zhong, Weidong;Watkins, William J. [ACS Medicinal Chemistry Letters,2011,vol. 2,# 10,p. 715 - 719] Location in patent:supporting information; experimental part
23095-05-8
147 suppliers
$19.00/1g
77-78-1
322 suppliers
$22.00/25g
90531-99-0
17 suppliers
$380.00/250mg
1203655-89-3
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74-88-4
351 suppliers
$15.00/10g
90531-99-0
17 suppliers
$380.00/250mg
3185-99-7
280 suppliers
$5.00/10g
90531-99-0
17 suppliers
$380.00/250mg