4-Bromo-1H-imidazole synthesis
- Product Name:4-Bromo-1H-imidazole
- CAS Number:2302-25-2
- Molecular formula:C3H3BrN2
- Molecular Weight:146.97
2034-22-2
183 suppliers
$9.00/10g
2302-25-2
246 suppliers
$6.00/1g
Yield:2302-25-2 89%
Reaction Conditions:
with sodium sulfite in water at 110; for 6 h;
Steps:
1.3 (3) Synthesis of 4-bromoimidazole (Intermediate 6)
To a single-necked flask was added 2,4,5-tribromoimidazole (49 g, 161 mmol)Sodium sulfite (101.5 g, 806 mmol)And water (500 ml) were added and stirred at 110 ° C for 6 h,Ethyl acetate was added,The organic layers were combined and dried over anhydrous sodium sulfate,Rotate the ethyl acetate to give compound 6 (20.5 g, yield 89%)
References:
Hinova Pharmaceuticals Inc.;Fan, Lei;Chen, Ke;Li, Xinghai;Chen, Yuanwei CN106256830, 2016, A Location in patent:Paragraph 0044; 0052; 0053; 0054
288-32-4
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$5.00/25g
2302-30-9
86 suppliers
$50.00/50mg
2302-25-2
246 suppliers
$6.00/1g
2302-30-9
86 suppliers
$50.00/50mg
2302-25-2
246 suppliers
$6.00/1g
64591-03-3
63 suppliers
$109.00/250 mg
2302-25-2
246 suppliers
$6.00/1g
288-32-4
964 suppliers
$5.00/25g
2302-30-9
86 suppliers
$50.00/50mg
2034-22-2
183 suppliers
$9.00/10g
2302-25-2
246 suppliers
$6.00/1g