ChemicalBook CAS DataBase List 4-bromo-2,6-dimethylbenzoic acid

4-bromo-2,6-dimethylbenzoic acid synthesis

8synthesis methods

Product Name:4-bromo-2,6-dimethylbenzoic acid
CAS Number:74346-19-3
Molecular formula:C9H9BrO2
Molecular Weight:229.07

124-38-9
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206559-43-5 Synthesis

206559-43-5
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74346-19-3
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$87.00/1g

Yield: 85%

Reaction Conditions:

Stage #1:carbon dioxide;5-bromo-2-iodo-1,3-dimethyl-benzene with isopropylmagnesium chloride in tert-butyl methyl ether at 0;Grignard Reaction;
Stage #2: with hydrogenchloride;water

Steps:

2
Example 2: Preparation of 4-bromo-2,6-dimethylbenzoic acid (B2)(B2)The title compound may be prepared according to Scheme B, as follows. A solution of 5- bromo-2-iodo-l,3-dimethyl-benzene (Bl) (1.0 mol eq) in methyl-tert-butyl ether (6.0 rel vols) may be added to iso-propylmagnesium chloride (2.0 mol eq) in methyl-tert-butyl ether (2.0 rel vols), maintaining < 0 °C. Carbon dioxide gas may be added until reaction is shown to be complete. 2N aqueous hydrochloric acid may be added (4 rel vols) to quench the reaction, the phases can be separated and the aqueous phase discarded. The product may be extracted into 1M aqueous sodium hydroxide solution (6.5 rel vols), then washed with methyl tert-butyl ether (4 rel vols). The title compound (B2) may be precipitated by the addition of 2N aq hydrochloric acid (4.5 rel vols) before being filtered, washed with water then heptane and dried to yield a white crystalline solid (85%).1H NMR (400 MHz, CDC1₃) δ_Η 2.28 (6 H, s), 7.35 (2 H, s), 13.30 (1H, s)

References:

ASTRAZENECA AB;BOYD, Alistair;FIELDING, Mark Richard;FORD, James Gair;FRODSHAM, Lianne;GOLDEN, Michael D;LESLIE, Kevin William;MCKEEVER-ABBAS, Ben;TOMLIN, Paula WO2011/84098, 2011, A1 Location in patent:Page/Page column 6-7

110-05-4 Synthesis