ChemicalBook CAS DataBase List 4-chloro-7-Methoxyquinoline-6-carboxaMide

4-chloro-7-Methoxyquinoline-6-carboxaMide synthesis

11synthesis methods

Product Name:4-chloro-7-Methoxyquinoline-6-carboxaMide
CAS Number:417721-36-9
Molecular formula:C11H9ClN2O2
Molecular Weight:236.65

398487-31-5 Synthesis

4-chloro-7-Methoxyquinoline-6-carbonitrile

398487-31-5
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4-chloro-7-Methoxyquinoline-6-carboxaMide

417721-36-9
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$8.00/250mg

Yield:417721-36-9 91%

Reaction Conditions:

with dihydrogen peroxide;potassium carbonate in dimethyl sulfoxide at 5 - 20;

Steps:

1.3; 2.3; 3.3

(3) Put 500g of Intermediate II into a 5L reaction flask, add 1.5L DMSO and 105g potassium carbonate, The molar ratio of intermediate II to potassium carbonate is 3:1, the temperature is controlled at 5-10°C, and 246mL hydrogen peroxide (30%) is added dropwise. The molar ratio of hydrogen peroxide to Intermediate II is 1.05:1. After the dropwise addition is completed, return to room temperature for reaction. After the reaction is completed, the reaction solution is added to ice water, filtered, washed with water, and dried to obtain 490 g of 4-chloro-7-methoxyquinoline-6-carboxamide with a yield of 91%.

References:

CN112110856,2020,A Location in patent:Paragraph 0006; 0018; 0020; 0022-0023; 0025

205448-66-4 Synthesis