4-chloro-7-Methoxyquinoline-6-carboxaMide synthesis
- Product Name:4-chloro-7-Methoxyquinoline-6-carboxaMide
- CAS Number:417721-36-9
- Molecular formula:C11H9ClN2O2
- Molecular Weight:236.65
398487-31-5
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Yield:417721-36-9 91%
Reaction Conditions:
with dihydrogen peroxide;potassium carbonate in dimethyl sulfoxide at 5 - 20;
Steps:
1.3; 2.3; 3.3
(3) Put 500g of Intermediate II into a 5L reaction flask, add 1.5L DMSO and 105g potassium carbonate, The molar ratio of intermediate II to potassium carbonate is 3:1, the temperature is controlled at 5-10°C, and 246mL hydrogen peroxide (30%) is added dropwise. The molar ratio of hydrogen peroxide to Intermediate II is 1.05:1. After the dropwise addition is completed, return to room temperature for reaction. After the reaction is completed, the reaction solution is added to ice water, filtered, washed with water, and dried to obtain 490 g of 4-chloro-7-methoxyquinoline-6-carboxamide with a yield of 91%.
References:
CN112110856,2020,A Location in patent:Paragraph 0006; 0018; 0020; 0022-0023; 0025
205448-66-4
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417721-36-9
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417721-36-9
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417721-35-8
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27492-84-8
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417721-36-9
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