ChemicalBook CAS DataBase List 4'-Ethylpropiophenone

4'-Ethylpropiophenone synthesis

5synthesis methods

Product Name:4'-Ethylpropiophenone
CAS Number:27465-51-6
Molecular formula:C11H14O
Molecular Weight:162.23

67-56-1 Synthesis

67-56-1
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$9.00/25ml

33967-18-9 Synthesis

33967-18-9
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$91.67/0.5g

27465-51-6
277 suppliers
$11.00/5g

Yield:27465-51-6 88%

Reaction Conditions:

with chlorine[2-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxypyridine](pentamethylcyclopentadienyl)iridium(III) chloride;potassium hydroxide in water at 80;Schlenk technique;Inert atmosphere;

Steps:

14

In a 10 mL Schlenk tube, methanol (1.1 mmol), 4-ethylphenethyl alcohol (1.0 mmol), KOH (1.1 mmol), H2O (2.0 mL) and TC-6 (0.1 mol%) were added. Under the protection of nitrogen, heat to 80°C for reaction. After completion, it was extracted with ethyl acetate (3×5.0 mL), the organic layers were combined, dried over anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure to obtain a crude product. The crude product was purified with a mixture of ethyl acetate/petroleum ether (1/50) as the eluent and purified by silica gel chromatography to obtain a pure product with a yield of 88%.

References:

CN112047797,2020,A Location in patent:Paragraph 0165-0172