4'-Fluoropropiophenone synthesis
- Product Name:4'-Fluoropropiophenone
- CAS Number:456-03-1
- Molecular formula:C9H9FO
- Molecular Weight:152.17
Yield:456-03-1 91%
Reaction Conditions:
with chlorine[2-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxypyridine](pentamethylcyclopentadienyl)iridium(III) chloride;potassium hydroxide in water at 80;Schlenk technique;Inert atmosphere;
Steps:
11
In a 10 mL Schlenk tube, methanol (1.1 mmol), 4-fluorophenethyl alcohol (1.0 mmol), KOH (1.1 mmol), H2O (2.0 mL) and TC-6 (0.1 mol%) were added. Under the protection of nitrogen, heat to 80°C for reaction. After completion, it was extracted with ethyl acetate (3×5.0 mL), the organic layers were combined, dried over anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure to obtain a crude product. The crude product was purified with a mixture of ethyl acetate/petroleum ether (1/50) as the eluent and purified by silica gel chromatography to obtain a pure product with a yield of 91%.
References:
CN112047797,2020,A Location in patent:Paragraph 0141-0148
104863-65-2
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456-03-1
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456-03-1
214 suppliers
$6.00/5g