4'-Hydroxy-4-biphenylcarbonitrile synthesis
- Product Name:4'-Hydroxy-4-biphenylcarbonitrile
- CAS Number:19812-93-2
- Molecular formula:C13H9NO
- Molecular Weight:195.22
![4'-CYANO[1,1'-BIPHENYL]-4-YL ACETATE](/StructureFile/ChemBookStructure4/GIF/CB9447080.gif)
127783-75-9
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19812-93-2
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Yield:19812-93-2 89.2%
Reaction Conditions:
with sodium hydroxide in ethanol at 70 - 80; for 1 h;
Steps:
5
4-Cyano-4'-acetic acid biphenyl (6.5g, 0.027mol) and sodium hydroxide solution (1N, 55ml) and 13ml of ethanol were added to a 200ml three-necked flask at room temperature, and heated to 70 ° C ~ 80 ° C reaction 1h, TLC detected no raw material points. The reaction solution was cooled to 0 ° C, hydrochloric acid (5%) was added dropwise, the pH of the system was adjusted to 5-6, the yellow solid was precipitated, stirred for 30 min, filtered, and washed with water until neutral, to obtain a yellowish solid, dried. 30 ml of ethyl acetate was dissolved at room temperature, 0.5 g of activated carbon was added, and the mixture was heated to 50 ° C for 1 hour, and the activated carbon was filtered, and the filtrate was passed through a column (silica gel 5 g), and concentrated to dryness to give a white solid 4.7 g (yield: 89.2%).
References:
CN107619381,2018,A Location in patent:Paragraph 0007; 0029
106-41-2
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126747-14-6
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19812-93-2
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![4'-methoxy[1,1'-biphenyl]-4-carbonitrile](/CAS/GIF/58743-77-4.gif)
58743-77-4
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19812-93-2
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623-03-0
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71597-85-8
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19812-93-2
271 suppliers
$6.00/1g