4-Methoxypyridine N-oxide synthesis
- Product Name:4-Methoxypyridine N-oxide
- CAS Number:1122-96-9
- Molecular formula:C6H7NO2
- Molecular Weight:125.13
620-08-6
315 suppliers
$5.00/1g
1122-96-9
176 suppliers
$22.00/1g
Yield:1122-96-9 88%
Reaction Conditions:
with dihydrogen peroxide;acetic acid in water for 24 h;Reflux;Inert atmosphere;
Steps:
14 Synthesis of 4-methoxypyridine 1-oxide
Synthesis of 4-methoxypyridine 1-oxide [0320] To a stirred solution of 4-methoxypyridine (5 g, 45.87 mmol) in acetic acid (25 mL) under argon atmosphere was added a 30%> hydrogen peroxide solution (4.2 mL) at RT. The reaction mixture was stirred at reflux for 24 h. After the consumption of the starting materials (monitored by TLC), the volatile components were removed in vacuo to afford 4- methoxypyridine 1-oxide (5 g, 88%>) as a yellow liquid. LC-MS: 125.9 (M+l); (column; Eclipse XDB C-18 (150 4.6 mm, 5.0 μιη); RT 5.02 min. 0.05% Aq TFA: ACN; 1.0 mL/min); TLC: 5% MeOH:CH2Cl2 (R 0.1).
References:
FORUM PHARMACEUTICALS INC.;BURNETT, Duane, A.;BURSAVICH, Matthew, Gregory;MCRINER, Andrew, J. WO2015/66697, 2015, A1 Location in patent:Paragraph 0320
1124-33-0
338 suppliers
$10.00/1g
124-41-4
716 suppliers
$12.00/25g
1122-96-9
176 suppliers
$22.00/1g
67-56-1
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$7.29/5ml-f
1124-33-0
338 suppliers
$10.00/1g
1122-96-9
176 suppliers
$22.00/1g
1124-33-0
338 suppliers
$10.00/1g
1122-96-9
176 suppliers
$22.00/1g