4-Methyl-[1,1'-biphenyl]-2-carbonitrile synthesis
11synthesis methods
- Product Name:4-Methyl-[1,1'-biphenyl]-2-carbonitrile
- CAS Number:64113-85-5
- Molecular formula:C14H11N
- Molecular Weight:193.24
Yield:64113-85-5 94%
Reaction Conditions:
with potassium carbonate in 5,5-dimethyl-1,3-cyclohexadiene;
Steps:
2 Example 2
Example 2 165 mmol of bromobenzonitrile, 247 mmol of 4-methylphenylboronic acid, 330 mmol of potassium carbonate are heated with 0.2 mol % of trans-di-acetato-bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) in 300 ml of xylene for 16 hours at 130° C. The reaction solution is distilled after aqueous workup. Yield: 94% of 2-cyano-4-methylbiphenyl.
References:
US5559277,1996,A
