ChemicalBook CAS DataBase List 4-(Trifluoromethoxy)benzoic acid

4-(Trifluoromethoxy)benzoic acid synthesis

5synthesis methods

Product Name:4-(Trifluoromethoxy)benzoic acid
CAS Number:330-12-1
Molecular formula:C8H5F3O3
Molecular Weight:206.12

332-25-2 Synthesis

332-25-2
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$7.00/5g

330-12-1
237 suppliers
$15.00/10 g

Yield:330-12-1 98%

Reaction Conditions:

with sulfuric acid;water;acetic acid at 120;

Steps:

7.2
4-(Trifluoromethoxy)benzoic acid: To a solution of 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) in acetic acid (12 mL) was added water (12 mL) and conc. H₂SO₄(12 mL). The reaction mixture was heated overnight at 120° C. Water (100 mL) was added to the reaction mixture and the aqueous solution was extracted from EtOAc (3×100 mL). The combined organic solution was dried (Na₂SO₄) and concentrated in vacuo to afford the title compound (4.8 g, 98%) as a white solid.

References:

KALYPSYS, INC. US2007/270434, 2007, A1 Location in patent:Page/Page column 16-17

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