ChemicalBook CAS DataBase List 4-(Trifluoromethoxy)benzoic acid

4-(Trifluoromethoxy)benzoic acid synthesis

5synthesis methods

Product Name:4-(Trifluoromethoxy)benzoic acid
CAS Number:330-12-1
Molecular formula:C8H5F3O3
Molecular Weight:206.12

332-25-2

330-12-1

Synthesis of 4-(trifluoromethoxy)benzoic acid: 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) was dissolved in acetic acid (12 mL), and water (12 mL) and concentrated sulfuric acid (12 mL) were added sequentially. The reaction mixture was stirred and reacted at 120 °C overnight. Upon completion of the reaction, water (100 mL) was added to the mixture and the aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound 4-(trifluoromethoxy)benzoic acid (4.8 g, 98% yield) as a white solid.

332-25-2 Synthesis

332-25-2
185 suppliers
$7.00/5g

330-12-1
249 suppliers
$15.00/10 g

Yield:330-12-1 98%

Reaction Conditions:

with sulfuric acid;water;acetic acid at 120;

Steps:

7.2
4-(Trifluoromethoxy)benzoic acid: To a solution of 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) in acetic acid (12 mL) was added water (12 mL) and conc. H₂SO₄(12 mL). The reaction mixture was heated overnight at 120° C. Water (100 mL) was added to the reaction mixture and the aqueous solution was extracted from EtOAc (3×100 mL). The combined organic solution was dried (Na₂SO₄) and concentrated in vacuo to afford the title compound (4.8 g, 98%) as a white solid.

References:

KALYPSYS, INC. US2007/270434, 2007, A1 Location in patent:Page/Page column 16-17

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