(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol synthesis

5synthesis methods

Product Name:(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol
CAS Number:953780-29-5
Molecular formula:C8H8F3NO2
Molecular Weight:207.15

40222-77-3 Synthesis

40222-77-3
61 suppliers
$61.00/100mg

6226-25-1 Synthesis

2,2,2-Trifluoroethyl trifluoromethanesulfonate

6226-25-1
253 suppliers
$11.19/5G

(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol

953780-29-5
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Yield:953780-29-5 41%

Reaction Conditions:

Stage #1: 3-Hydroxy-6-pyridine-methanolwith potassium carbonate in N,N-dimethyl-formamide at 20; for 0.25 h;
Stage #2: 2,2,2-trifluoroethyl trifluoromethanesulphonate at 120; for 24 h;

References:

Arteaga, Janna;Brooks, Allen F.;Desmond, Timothy J.;Kaur, Tanpreet;Lapsys, Alex;Scott, Peter J. H.;Stauff, Jenelle;Winton, Wade P. [Frontiers in Neuroscience,2021,vol. 15,art. no. 766176]

2-methyl-5-(2,2,2-trifluoroethoxy)pyridine 1-oxide

953780-28-4
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108-24-7
5 suppliers
$14.00/250ML

953780-29-5
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References

1121-78-4 Synthesis

1121-78-4
292 suppliers
$6.00/5g

953780-29-5
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References

2-methyl-5-(2,2,2-trifluoroethoxy)pyridine

864263-61-6
3 suppliers
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953780-29-5
12 suppliers
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References

953780-28-4
3 suppliers
inquiry

953780-29-5
12 suppliers
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References