3-Hydroxy-6-methylpyridine synthesis
- Product Name:3-Hydroxy-6-methylpyridine
- CAS Number:1121-78-4
- Molecular formula:C6H7NO
- Molecular Weight:109.13
55270-47-8
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$65.00/100mg
1121-78-4
289 suppliers
$6.00/5g
Yield:1121-78-4 84%
Reaction Conditions:
with L-Selectride in tetrahydrofuran for 24 h;Reflux;Inert atmosphere;chemoselective reaction;
Steps:
Demethylation of Methoxypyridines; General Procedure:
General procedure: Toa solution of 1 (1.00 mmol) in THF (7.0 mL) was added L-selectride(1 M in THF, 3.0 mL, 3.00 mmol, 3 equiv) under an argonatmosphere. After being refluxed and monitored by TLC, thereaction mixture was quenched with MeOH and evaporated invacuo. The residue was purified by silica gel column chromatographyto give the desired compound 2.
References:
Makino, Kosho;Hasegawa, Yumi;Inoue, Takahide;Araki, Koji;Tabata, Hidetsugu;Oshitari, Tetsuta;Ito, Kiyomi;Natsugari, Hideaki;Takahashi, Hideyo [Synlett,2019,vol. 30,# 8,p. 951 - 954]
3430-13-5
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1121-78-4
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$6.00/5g
4808-69-9
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$19.00/100mg
1121-78-4
289 suppliers
$6.00/5g
620-02-0
497 suppliers
$14.14/5gm:
1121-78-4
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$6.00/5g
50-00-0
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$10.00/25g
617-89-0
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$15.00/25mL
1121-78-4
289 suppliers
$6.00/5g