5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril synthesis
- Product Name:5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril
- CAS Number:51781-14-7
- Molecular formula:C12H13NO3
- Molecular Weight:219.24
30389-33-4
207 suppliers
$15.00/250mg
106-89-8
778 suppliers
$9.00/10g
51781-14-7
28 suppliers
$165.00/10mg
Yield:51781-14-7 63.6%
Reaction Conditions:
Stage #1: 5-hydroxycarbostyrilwith sodium hydroxide for 0.166667 h;
Stage #2: epichlorohydrin at 55 - 60; for 4 h;Temperature;
Steps:
5.d Step d: Preparation of 5- (2,3-epoxypropoxy) -3,4-dihydro-2 (1-per- quinolone
Hydroxy-3,4-dihydro-2 (1H) -quinolone (0.015 mol) was dissolved in a 0.2 mol / L sodium hydroxide solution (the amount of sodium hydroxide was 5-hydroxy- - dihydro-2 (1H) -quinolone 0.5 molar times), stirred 10min, was added epichlorohydrin (0.03mol), 55 ~ 60 ° C the reaction was stirred for about 4h, resulting in a large amount of white floc, TLC test After the reaction was completed, the solution was cooled to room temperature, ethyl acetate was added (its amount was 1 time the volume of the reaction solution), the sub-water was removed by a separatory funnel, filtered, and the filter cake was recrystallized from acetone to give the white powdery solid 5- , 3-glycidyloxy) -3,4-dihydro-2 (1H) -quinolone (yield 63.6%),
References:
CN107337639,2017,A Location in patent:Paragraph 0120-0121; 0129; 0141; 0152; 0163; 0173-0174; 0185
30389-33-4
207 suppliers
$15.00/250mg
3132-64-7
126 suppliers
$20.00/1g
51781-14-7
28 suppliers
$165.00/10mg
30389-33-4
207 suppliers
$15.00/250mg
106-89-8
778 suppliers
$9.00/10g
51781-14-7
28 suppliers
$165.00/10mg
51781-13-6
16 suppliers
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