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Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 5-BROMO-2-HYDROXYBENZONITRILE
40530-18-5

5-BROMO-2-HYDROXYBENZONITRILE synthesis

11synthesis methods
5-Bromosalicylaldehyde

1761-61-1
390 suppliers
$5.00/5g

5-BROMO-2-HYDROXYBENZONITRILE

40530-18-5
184 suppliers
$15.00/1g

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Yield:40530-18-5 95%

Reaction Conditions:

with formic acid;hydroxylamine hydrochloride;sodium formate at 100; for 7 h;

Steps:

1

5-Bromo-2-hydroxybenzonitrile; To a solution of 5-bromosalicylaldehyde (80.0 g, 0.40 mol) in formic acid were added hydroxylamine hydrochloride (36.0 g, 0.52 mol) and sodium format (37.0 g, 0.52 mol) followed by stirring at 100°C for 7 hours. Ethyl acetate was added to the residue prepared by evaporation of the solvent, the mixture was washed with water and then an organic layer was dried. Petroleum ether was added to the residue prepared by evaporation of the solvent and the crystals separated out therefrom were filtered to give the title compound (75.2 g, 95%). 1H-NMR (DMSO-d6) δ: 6.98 (d, J=8.9 Hz, 1H), 7.65 (dd, J=8.9, 2.4 Hz, 1H), 7.86 (d, J=2.4 Hz, 1H), 11.41 (s, 1H).

References:

EP2128136,2009,A1 Location in patent:Page/Page column 7

5-Bromo-2-methoxybenzonitrile

144649-99-0
129 suppliers
$6.00/250mg

5-BROMO-2-HYDROXYBENZONITRILE

40530-18-5
184 suppliers
$15.00/1g

References
82486-43-9 Synthesis
5-BROMO-2-HYDROXYBENZALDEHYDE OXIME

82486-43-9
17 suppliers
$45.00/250mg

5-BROMO-2-HYDROXYBENZONITRILE

40530-18-5
184 suppliers
$15.00/1g

References
50-00-0 Synthesis
Formaldehyde

50-00-0
892 suppliers
$10.00/25g

4-Bromophenol

106-41-2
502 suppliers
$13.00/5g

5-BROMO-2-HYDROXYBENZONITRILE

40530-18-5
184 suppliers
$15.00/1g

References
4-BROMO-2-METHYLANISOLE

14804-31-0
161 suppliers
$7.00/5g

5-BROMO-2-HYDROXYBENZONITRILE

40530-18-5
184 suppliers
$15.00/1g

References

5-BROMO-2-HYDROXYBENZONITRILE Related Search:

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