5-BROMO-2-(METHYLTHIO)PYRIMIDINE synthesis
- Product Name:5-BROMO-2-(METHYLTHIO)PYRIMIDINE
- CAS Number:14001-67-3
- Molecular formula:C5H5BrN2S
- Molecular Weight:205.08
74-93-1
141 suppliers
$454.02/5MG
32779-36-5
653 suppliers
$5.00/5g
14001-67-3
139 suppliers
$8.00/250mg
Yield:14001-67-3 75%
Reaction Conditions:
in N,N-dimethyl-formamide at 50; for 3 h;
Steps:
24.1 Step 1: Synthesis of 5-bromo-2-(methylthio)pyrimidine
Step 1:
Synthesis of 5-bromo-2-(methylthio)pyrimidine
To a stirred solution of 5-bromo-2-chloropyrimidine (0.3 g, 1.563 mmol) in DMF (10 mL) was added methyl mercaptan (0.1 mL, 1.563 mmol) at room temperature and heat at 50° C. for 3 h.
Completion of reaction was monitored by TLC.
Reaction mixture was quenched by addition of water, extracted with EtOAc.
Organic portions were combined, dried over Na2SO4, evaporated under reduced pressure to obtain crude which was purified by column chromatography using silica gel (100-200 mesh); eluent 5% ethyl acetate/hexane to obtain pure product 5-bromo-2-(methylthio)pyrimidine (0.240 g, 75%) as white solid.
MS: 205.1[M++1]
References:
US2017/291910,2017,A1 Location in patent:Paragraph 0496-0498
32779-36-5
653 suppliers
$5.00/5g
5188-07-8
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$13.00/5g
14001-67-3
139 suppliers
$8.00/250mg
124405-67-0
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$20.00/100mg
5188-07-8
287 suppliers
$13.00/5g
14001-67-3
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$8.00/250mg
823-09-6
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$56.00/250mg
14001-67-3
139 suppliers
$8.00/250mg
63810-78-6
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$9.00/250mg
14001-67-3
139 suppliers
$8.00/250mg