Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 5-Bromo-3-cyano-2-hydroxypyridine
405224-22-8

5-Bromo-3-cyano-2-hydroxypyridine synthesis

2synthesis methods
20577-27-9 Synthesis
2-Hydroxy-3-cyanopyridine

20577-27-9
167 suppliers
$14.00/1g

5-Bromo-3-cyano-2-hydroxypyridine

405224-22-8
111 suppliers
inquiry

-

Yield:405224-22-8 88%

Reaction Conditions:

Stage #1: pyrid-2-one-3-carbonitrilewith acetic acid at 130;
Stage #2: with bromine for 3 h;

Steps:

1.2 Step 2: 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile

Acetic acid (34 ml) was added to 2-oxo-1,2-dihydropyridine-3-carbonitrile (6.28 g, 0.052 mol) and the mixture was heated to 130°C. When the solid was dissolved, bromine (12.5 g, 0.078 mol) was added slowly and stirred at the same temperature for 3 hours.After the reaction solution was cooled to room temperature, dichloromethane and water were added. The organic layer was separated and the aqueous layer was washed with dichloromethane. The organic layer was collected, washed with brine, dried over anhydrous sodium sulfate and concentrated to give the desired compound (9.11 g, 88% yield) as a yellow solid.

References:

KR101936851,2019,B1 Location in patent:Paragraph 0173; 0181-0184

5-Bromo-3-cyano-2-hydroxypyridine Related Search: