5-Cyano-2-methoxybenzaldehyde synthesis
- Product Name:5-Cyano-2-methoxybenzaldehyde
- CAS Number:21962-53-8
- Molecular formula:C9H7NO2
- Molecular Weight:161.16
67-56-1
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146137-79-3
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$9.00/250mg
21962-53-8
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$48.39/250mg
Yield: 88%
Reaction Conditions:
with sodium methylate at 20;
Steps:
38.1 Step 1: 5-cyano-2-methoxybenzaldehyde (38a).
To a solution of 5-cyano-2-fluorobenzaldehyde (500 mg, 3.35 mmol) in MeOH (5 mL) was added CH3ONa (362 mg, 6.71 mmol, 2 equiv). The mixture was stirred at rt for 3 h. After the reaction was completed, the product was extracted with EtOAc (20 mL x 3). The organic layers were combined, washed with saturated brine, dried over Na2SO4 and filtered. All volatiles were evaporated in vacuo and the product was obtained after flash chromatography (hexane: EtOAc = 30: 1) as a white solid (478 mg, 88%), 1H NMR (400 MHz, Chloroform-d) δ 10.44 (s, 1H), 8.13 (s, 1H), 7.84 (d, J = 8.8 Hz, 1H), 7.12 (d, J = 8.9 Hz, 1H), 4.04 (s, 3H).
References:
Qiu, Yangyi;Chan, Shu Ting;Lin, Lin;Shek, Tsun Lam;Tsang, Tsz Fung;Barua, Nilakshi;Zhang, Yufeng;Ip, Margaret;Chan, Paul Kay-sheung;Blanchard, Nicolas;Hanquet, Gilles;Zuo, Zhong;Yang, Xiao;Ma, Cong [European Journal of Medicinal Chemistry,2019,vol. 178,p. 214 - 231]
557-21-1
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$12.00/5g
25016-01-7
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$6.00/5g
21962-53-8
37 suppliers
$48.39/250mg
124-41-4
726 suppliers
$12.00/25g
146137-79-3
157 suppliers
$9.00/250mg
21962-53-8
37 suppliers
$48.39/250mg
544-92-3
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$9.00/1g
25016-01-7
233 suppliers
$6.00/5g
21962-53-8
37 suppliers
$48.39/250mg