5-FLUORO-2-PHENYLBENZO[D]THIAZOLE synthesis
- Product Name:5-FLUORO-2-PHENYLBENZO[D]THIAZOLE
- CAS Number:1629-93-2
- Molecular formula:C13H8FNS
- Molecular Weight:229.27
1629-04-5
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1629-93-2
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Yield:1629-93-2 96%
Reaction Conditions:
with sodium salt of phosphorous acid in dimethyl sulfoxide; for 5 h;Inert atmosphere;Irradiation;
Steps:
3 Example 3: Visible light promotes the reaction of N-(2-bromo-5fluorophenyl)thiobenzamide.
Add N-(2-bromo-5fluorophenyl)thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO (2 mL) into a dry reaction tube with a magnetic stirrer, and then the reaction Replace the tube with N2 3 times, under the illumination of a 45W household compact fluorescent lamp,The reaction was stirred for 5 h. After the reaction, 4 mL of water was added, and then extracted with 3×4 mL of ethyl acetate. The organic phases were combined, and the organic phases were dried with anhydrous sodium sulfate and filtered.After the filtrate is concentrated by rotary evaporation, it is separated by thin layer chromatography on silica gel chromatography to obtain the target product.The yield was 96%.
References:
CN112979581,2021,A Location in patent:Paragraph 0031-0033
