ChemicalBook CAS DataBase List 5-FLUOROINDOLE-3-CARBOXYLIC ACID

5-FLUOROINDOLE-3-CARBOXYLIC ACID synthesis

6synthesis methods

Product Name:5-FLUOROINDOLE-3-CARBOXYLIC ACID
CAS Number:23077-43-2
Molecular formula:C9H6FNO2
Molecular Weight:179.15

2,2,2-Trifluoro-1-(5-fluoro-3-indolyl)ethanone

1260793-83-6
13 suppliers
inquiry

23077-43-2
114 suppliers
$27.00/100mg

Yield:23077-43-2 785 mg

Reaction Conditions:

with sodium hydroxide in water; for 1.5 h;Reflux;

Steps:

113-2 (113-2) Synthesis of 5-Fluoro-lH-indole-3-carboxylic acid(Compound 113-2)

2,2,2 trifluoro-1-[5-fluoro-l- (pyrimidin-2-yl)-1H-indol-3-yl] ethan-1-one(1.6 g)Was added 5 N sodium hydroxide aqueous solution (20 mL)And the mixture was stirred under heating reflux for 1.5 hours.After cooling the reaction solution to room temperature, water and ethyl acetate were added,And extracted with ethyl acetate. The obtained aqueous layer was made acidic with concentrated hydrochloric acid,The mixture was extracted with ethyl acetate and washed with saturated brine. The organic layer was dried over sodium sulfate and the solvent was distilled off under reduced pressure to give 5-fluoro-lH-indole-3-carboxylic acid785 mg (yield 88%) was obtained.

References:

JP2017/171619,2017,A Location in patent:Paragraph 0168; 0170

399-52-0 Synthesis