5-Methyl-2-nitrophenol synthesis
- Product Name:5-Methyl-2-nitrophenol
- CAS Number:700-38-9
- Molecular formula:C7H7NO3
- Molecular Weight:153.14
Yield:700-38-9 87% ，2581-34-2 5%
Reaction Conditions:
with silica supported Al(NO3)3*9H2O in acetone at 20; for 0.416667 h;regioselective reaction;
Steps:
Typical Experimental Procedure for the Nitration of Phenol
General procedure: To a solution of phenol (1 mmol) in acetone (5 mL) wasadded silica supported Al(NO3)3·9H2O (1 mmol) and theresulting mixture stirred at room temperature. After completionof the reaction, as indicated by TLC, the reaction masswas filtered and the residue (silica) was washed with ethylacetate (2 5 mL). The filtrate and the washing were collectivelyconcentrated under reduced pressure, and the crudecompound was purified by column chromatography oversilica gel (100-200 mesh) to afford the pure ortho-nitro phenol(95%) and para- nitro phenol (3%).
References:
Patil, Mahadeo R.;Mohite, Pravinkumar H.;Shisodia, Suresh;Keri, Rangappa S. [Letters in Organic Chemistry,2015,vol. 12,# 2,p. 129 - 135]
108-39-4
458 suppliers
$13.00/25g
700-38-9
175 suppliers
$6.00/5g
108-39-4
458 suppliers
$13.00/25g
700-38-9
175 suppliers
$6.00/5g
2581-34-2
259 suppliers
$10.00/5G
4920-77-8
211 suppliers
$15.00/5g
2835-98-5
238 suppliers
$8.00/5g
700-38-9
175 suppliers
$6.00/5g