6-Amino-m-cresol synthesis
- Product Name:6-Amino-m-cresol
- CAS Number:2835-98-5
- Molecular formula:C7H9NO
- Molecular Weight:123.15
700-38-9
2835-98-5
The general procedure for the synthesis of 6-aminoresorcinol from 6-nitroresorcinol was as follows: 5-methyl-2-nitrophenol (1.0 g, 6.53 mmol) was dissolved in methanol (10 mL) at 23 °C, and Pd/C catalyst (10 wt%, 400 mg) was added. The reaction mixture was deoxygenated at low temperature, followed by replacement of air in the system with hydrogen (supplied via a balloon). After the reaction was stirred for 5 h under hydrogen atmosphere, the reaction mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with methanol (100 mL). Finally, the combined filtrates were concentrated under reduced pressure to afford 2-amino-5-methylphenol (801 mg, 100% yield).
700-38-9
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2835-98-5
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Yield:2835-98-5 100%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 23; for 5 h;
Steps:
82
To a solution of 5-methyl-2-nitrophenol (1.0 g, 6.53 mmol) in methanol (10 mL) at 23° C. was added Pd/C (10 wt %, 400 mg), and the reaction mixture was deoxygenated under vacuum, then purged with hydrogen in a balloon. After stirring for 5 h, the reaction mixture was filtered through a pad of Celite and the Celite pad was rinsed with methanol (100 mL). The filtrate was concentrated in vacuo to yield 2-amino-5-methylphenol (801 mg, 100%).
References:
US2006/211603,2006,A1 Location in patent:Page/Page column 69
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