5-Trifluoromethyl-pyridin-3-ylamine synthesis
- Product Name:5-Trifluoromethyl-pyridin-3-ylamine
- CAS Number:112110-07-3
- Molecular formula:C6H5F3N2
- Molecular Weight:162.11
1529769-93-4
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112110-07-3
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Yield: 90%
Reaction Conditions:
with hydrogenchloride in tetrahydrofuran;water at 20; for 2 h;
Steps:
2 Step 2: Synthesis of 5-(trifluoromethyl)pyridin-3-amine
Dissolve the imine obtained in Step 1 (850 mg, 2.6 mmol) in THF (10 mL), add water (2 mL), IN HCI solution (5 mL), stir the reaction at room temperature for 2 hrs. After the reaction, extract with EtOAc, wash the organic layer with saturated NaHC03 solution and brine sequentially, dry over anhydrous Na2S04, and concentrate under reduced pressure to give the crude product. Purification by chromatography (silica gel, EtOAc:PE=l :l) affords the target compound (380 mg, 90%).
References:
CROWN BIOSCIENCE INC. (TAICANG);ZHANG, Deyi;ZHANG, Ruihao;ZHONG, Boyu;SHIH, Chuan WO2014/418, 2014, A1 Location in patent:Page/Page column 83
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112110-07-3
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112110-07-3
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112110-07-3
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112110-07-3
145 suppliers
$19.00/250mg