1-Propanone, 1-[4-(methylthio)phenyl]- (9CI) Propiophenone, 4'-(methylthio) synthesis
- Product Name:1-Propanone, 1-[4-(methylthio)phenyl]- (9CI) Propiophenone, 4'-(methylthio)
- CAS Number:52129-99-4
- Molecular formula:C10H12OS
- Molecular Weight:180.27
Yield:-
Reaction Conditions:
with hydrogenchloride;aluminium trichloride in carbon disulfide;propionic acid anhydride;
Steps:
R.10 Production of 2-bromo-4'-methylthiopropiophenone
Reference Example 10 Production of 2-bromo-4'-methylthiopropiophenone Propionic anhydride (93 ml) was gradually added dropwise to a solution of 100 g of thioanisole and 240 g of anhydrous aluminum chloride in 250 ml of carbon disulfide, and the mixture was stirred at 40° C. for 2 hours. The reaction mixture was poured gradually into ice-cooled 3N hydrochloric acid and extracted with dichloromethane. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. n-Hexane was added to the residue and the resultant crystals were collected by filtration and further washed with n-hexane. Thus was obtained 92.0 g of 4'-methylthiopropiophenone as crystals (m.p. 55°-56° C.). 1 H-NMR (δ: ppm): [Solvent: CDCl3 ] 1.21 (3H, t, J=7.3), 2.52 (3H, s), 2.95 (2H, q, J=7.3), 7.26 (2H, d, J=8.6), 7.88 (2H, d, J=8.6)
References:
US5496844,1996,A
74-85-1
113 suppliers
$79.00/11l
13205-48-6
148 suppliers
$31.80/1gm:
52129-99-4
14 suppliers
inquiry
89434-30-0
3 suppliers
inquiry
52129-99-4
14 suppliers
inquiry
