6-(4-FLUOROPHENYL)-3(2H)-PYRIDAZINONE synthesis
- Product Name:6-(4-FLUOROPHENYL)-3(2H)-PYRIDAZINONE
- CAS Number:58897-67-9
- Molecular formula:C10H7FN2O
- Molecular Weight:190.17
66548-52-5
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58897-67-9
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Yield:58897-67-9 99%
Reaction Conditions:
with acetic acid at 120; for 4 h;
Steps:
6-(3-Fluorophenyl)pyridazine-3(2H)-one
General procedure: A solution of 3-chloro-6-(3-fluorophenyl)pyridazine (109 mg, 0.52 mmol) in acetic acid (2 mL) was stirred at 120°C for 4 h. After concentration to remove acetic acid, the resulting solid was washed with H2O, and dried to afford 6-(3-fluorophenyl)pyridazine-3(2H)-one (83%)
References:
Kang, Seung-Tae;Kim, Eun-Young;Archary, Raghavendra;Jung, Heejung;Park, Chi Hoon;Yun, Chang-Soo;Hwang, Jong Yeon;Choi, Sang Un;Chae, Chonghak;Lee, Chong Ock;Kim, Hyoung Rae;Ha, Jae Du;Ryu, Dohyun;Cho, Sung Yun [Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,# 21,p. 5093 - 5097] Location in patent:supporting information
39499-62-2
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58897-67-9
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403-42-9
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298-12-4
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58897-67-9
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1336-21-6
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403-42-9
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6000-59-5
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58897-67-9
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