6-Aminopyridine-2-carboxylic acid synthesis
- Product Name:6-Aminopyridine-2-carboxylic acid
- CAS Number:23628-31-1
- Molecular formula:C6H6N2O2
- Molecular Weight:138.12
26893-72-1
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$75.00/500 mg
23628-31-1
255 suppliers
$6.00/1g
Yield:23628-31-1 76%
Reaction Conditions:
in sodium hydroxide
Steps:
L.B Step B
Step B A suspension of 2-acetylaminopyridine-6-carboxylic acid (4.1 g) in 2.5 N NaOH (36.5 ml) was heated at 80° C. for 1.5 hours, under nitrogen atmosphere. The resulting solution was cooled and acidified with cold 3N HCl. The precipitate obtained was filtered, washed successively with water and acetonitrile. The resulting white solid was dried under vacuum to afford 2-aminopyridine-6-carboxylic acid (2.4 g, 76% yield). 1H-NMR (DMSO-d6) δ 7.57 (t, 1H, J=8.1 Hz), 7.14 (d, 1H, J=7.2 Hz), 6.67 (1H, J=8.1 Hz), 6.51 (br, 2H); FAB MS m/z 139 (M+H).
References:
G. D. Searle & Co. US6689754, 2004, B1
4684-94-0
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23628-31-1
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5327-33-3
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$25.00/5g
23628-31-1
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$6.00/1g
1824-81-3
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$8.00/25g
23628-31-1
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$6.00/1g
21190-87-4
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$10.00/5g
23628-31-1
255 suppliers
$6.00/1g