6-Chloro-4-methoxypyridine-3-carbaldehyde synthesis
- Product Name:6-Chloro-4-methoxypyridine-3-carbaldehyde
- CAS Number:1256823-05-8
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58
1060811-62-2
135 suppliers
$15.00/100mg
124-41-4
716 suppliers
$12.00/25g
1256823-05-8
47 suppliers
$95.00/250mg
Yield:1256823-05-8 57%
Reaction Conditions:
in methanol at 0 - 25; for 21 h;Inert atmosphere;
Steps:
7 Preparation of 6-chloro-4-methoxynicotinaldehyde
Sodium methoxide (0.068 g, 1.25 mmol) was added portionwise to a stirred solution of 4,6-dichloronicotinaldehyde (0.2 g, 1.14 mmol) in MeOH (10 mL) cooled to 0°C. The reaction was allowed to warm to room temperature (over 5 hours) and stirred at roomtemperature for 16 hours. The reaction was concentrated in vacuo and then dissolved in DCM. Solids were removed by filtration and the filtrate was purified by flash silica chromatography, elution gradient 0 to 50% EtOAc in heptane. Pure fractions were evaporated to dryness to afford 6-chloro-4-methoxynicotinaldehyde (0.111 g, 57%) as a white solid. ‘H NMR (500 MHz, CDC13, 22 °C) 4.02 (3H, s), 6.97 (1H, s), 8.69 (1H, s),10.37 (1H, d). nz/z: ES+ [M+H]+ 172.
References:
WO2018/19793,2018,A1 Location in patent:Page/Page column 126; 127
84332-02-5
66 suppliers
$65.00/100mg
1256823-05-8
47 suppliers
$95.00/250mg
40296-46-6
332 suppliers
$6.00/1g
1256823-05-8
47 suppliers
$95.00/250mg
1830-54-2
405 suppliers
$9.00/10g
1256823-05-8
47 suppliers
$95.00/250mg
79398-27-9
124 suppliers
$11.00/250mg
1256823-05-8
47 suppliers
$95.00/250mg