6-Methyl-4-phenylchroman-2-one synthesis
- Product Name:6-Methyl-4-phenylchroman-2-one
- CAS Number:40546-94-9
- Molecular formula:C16H14O2
- Molecular Weight:238.28
106-44-5
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621-82-9
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40546-94-9
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Yield: 97%
Reaction Conditions:
with sulfuric acid in xylene at 140 - 145;
Steps:
1
A mixture of 0.5 kg cinnamic acid, 0.401 kg p-cresol and 2.2 L xylene was stirred for 15 minutes. 0.132 kg cone, sulfuric acid was added under stirring. After completion of acid addition, reaction mixture was stirred at 140-1450C. After the completion of reaction, reaction was cooled at RT then washed with 1.0 L DM water. The reaction mixture was cooled at 10-150C & solution of 0.5 N NaOH in DM water was added drop wise & stirred reaction mixture at same temperature for 1 hr. The organic layer was separated & washed with DM water. Organic layer was distilled out completely under reduced pressure (30-40 mm Hg) to obtain 3,4-dihydro-6-methyl - 4-phenyl-2H-benzopyran-2-one (Yield: 0.78 kg, 97%).[151] HPLC Purity: > 95 %.
References:
ALEMBIC LIMITED;PONNAIAH, Ravi;DESAI, Sanjay;SHAH, Chankrakant Chunilal;PATEL, Kalpesh Shantibhai;PAREKH, Viral Maheshbhai WO2010/46801, 2010, A2 Location in patent:Page/Page column 15
106-44-5
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140-10-3
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40546-94-9
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$47.00/5g
16299-22-2
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40546-94-9
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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16299-22-2
12 suppliers
$275.00/250 mg
40546-94-9
170 suppliers
$47.00/5g